We study cellular systems by comparing genome data across many species.

Large-scale efforts in genome sequencing have elucidated much of the “parts list” for thousands of species, but a general description of how genes collectively interact to produce functioning systems eludes us. We use statistical analysis of genome sequences drawn from thousands of organisms to distill out general patterns describing the organization of cellular systems and individual proteins. By examining the conservation and co-evolution of genetic information across species, we can understand which cellular components are critical, infer functional interactions, and identify modular gene groups.

An important aspect of the lab is experimentally testing these statistical models for their ability to explain, predict, and design cellular behaviors. To do this, our lab has developed an infrastructure that permits: (1) deep scanning mutagenesis of genes (2) genome-wide second site suppressor screens under varying environmental conditions, and (3) high throughput measurements of fitness and genetic epistasis with excellent accuracy. We are broadly interested in new techniques for studying molecular evolution and strategies for synthetic biology.

For additional information, you can also check out this brief introduction to the lab, intended for prospective graduate students.

We are hiring! If you are interested in joining as a postdoctoral fellow please send an email with your CV and a statement of your interests to Kim.

News and Twitter

Sept. 9, 2019

Congratulations Dr. Schober on an excellent thesis defense!

Andrew (left) and Kim (right)

May. 10, 2019

Congratulations to lab members Andrew Schober, Andrew Mathis, and Christine Ingle! Our paper on adaptive units in metabolism is accepted at Cell Reports. Check out the preprint on BioRxiv.

Mar. 3, 2019

Kim presents the lab’s work on evolution of allostery at Biophysical Society. Session on Proteins: Exploring sequence space via computation and experiment.

Dec. 8, 2018

Kim is presenting in the ASCB subgroup on evolutionary cell biology.

Nov, 2018

Our new paper on engineering phosphoregulation in protein kinases is out in Science Signaling! [link]

Oct 18, 2018

Kim is speaking on allosteric regulation in kinases at the North Eastern Structure   Symposium in Farmington, CT

July 7, 2018

Kim is a keynote speaker at the Function COSI, ISMB Chicago

June 26-29, 2018

The Reynolds lab road-tripped to the annual Q-bio meeting at Rice University.

At the museum of Natural History, Houston – Opening reception for Qbio

June 18, 2018

Kim is speaking at Protein Engineering Canada

March 27, 2018

Kim is giving the Biology seminar at Texas A&M University

Jan. 29-Feb.1,  2018

Kim is attending the Gordon and Betty Moore annual data driven discovery symposium

Dec. 7, 2017

Kim is giving the MBS seminar at Northwestern

Oct 29, 2017

Kim is a keynote speaker at the Australasian genomic technologies association (AGTA) meeting in Hobart, Tasmania